- 专利标题： PHARMACEUTICAL COMPOSITIONS COMPRISING BISPECIFIC ANTI-CD3, ANTI-CD19 ANTIBODY CONSTRUCTS FOR THE TREATMENT OF B-CELL RELATED DISORDERS
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申请号： EP04739378.0申请日： 2004-05-26
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公开(公告)号： EP1629012B1公开(公告)日： 2018-11-28
- 发明人: KUFER, Peter , LUTTERBÜSE, Ralf , KOHLEISEN, Birgit , ZEMAN, Steven , BÄUERLE, Patrick
- 申请人： Amgen Research (Munich) GmbH
- 申请人地址： Staffelseestrasse 2 81477 München DE
- 专利权人： Amgen Research (Munich) GmbH
- 当前专利权人： Amgen Research (Munich) GmbH
- 当前专利权人地址： Staffelseestrasse 2 81477 München DE
- 代理机构： Schiweck Weinzierl Koch Patentanwälte Partnerschaft mbB
- 优先权： EP03012136 20030531
- 国际公布： WO2004106381 20041209
- 主分类号： C07K16/28
- IPC分类号： C07K16/28 ; A61K39/395 ; A61P35/00 ; A61P35/02 ; A61P19/02
摘要：
The present invention relates to a pharmaceutical composition comprising a bispecific single chain antibody construct comprising binding domains specific for human CD3 and human CD19, wherein the corresponding variable heavy chain regions (VH) and the corresponding variable light chain regions (VL) regions are arranged, from N-terminus to C-terminus, in the order VH(CD19)-VL(CD19)-VH(CD3)-VL(CD3) or VH(CD3)-VL-(CD3)-VH(CD19)-VL (CD19). Processes for the production of the pharmaceutical compositions and medical/pharmaceutical uses for the specific bispecific single chain antibody molecules bearing specificities for the human CD3 antigen and the human CD19 antigen are also disclosed.
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