发明公开
EP1631661A2 TRANSGENIC ANIMAL HAVING AN AMYLOID PRECURSOR PROTEIN WITH A MODIFIED BETA SECRETASE CLEAVAGE SITE
审中-公开
用改性β-分泌接口的转基因淀粉样前体蛋白的动物
- 专利标题： TRANSGENIC ANIMAL HAVING AN AMYLOID PRECURSOR PROTEIN WITH A MODIFIED BETA SECRETASE CLEAVAGE SITE
- 专利标题（中）： 用改性β-分泌接口的转基因淀粉样前体蛋白的动物
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申请号： EP04753635.4申请日： 2004-05-28
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公开(公告)号： EP1631661A2公开(公告)日： 2006-03-08
- 发明人: CHEN, Richard, Z. , SIMON, Adam, J. , VOGT, Thomas, F.
- 申请人： Merck & Co., Inc.
- 申请人地址： 126 East Lincoln Avenue Rahway, New Jersey 07065-0907 US
- 专利权人： Merck & Co., Inc.
- 当前专利权人： Merck & Co., Inc.
- 当前专利权人地址： 126 East Lincoln Avenue Rahway, New Jersey 07065-0907 US
- 代理机构： Man, Jocelyn
- 优先权： US474772P 20030530; US518591P 20031107
- 国际公布： WO2004111189 20041223
- 主分类号： C12N5/00
- IPC分类号： C12N5/00 ; C12N15/00 ; A01K67/00 ; G01N33/00
摘要：
The present invention provides transgenic animals having an amyloid precursor protein wherein the amino acids flanking the β secretase cleavage site are NF and EV. The invention also provides tissues and cell lines derived from such animals. The invention further provides methods of screening candidate compounds to determine whether the compounds can alter the rate of cleavage of amyloid precursor protein by β secretase.
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