发明公开
- 专利标题: MENTHOL-CONTAINING PREPARATION
- 专利标题(中): 薄荷醇的制备含
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申请号: EP04746565申请日: 2004-06-28
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公开(公告)号: EP1640022A4公开(公告)日: 2008-08-06
- 发明人: HAMAWAKI TOMONORI , KATAOKA YOSUKE , ISODA TAKAKO
- 申请人: NIHON PHARMACEUTICAL CO LTD
- 专利权人: NIHON PHARMACEUTICAL CO LTD
- 当前专利权人: NIHON PHARMACEUTICAL CO LTD
- 优先权: JP2003186493 2003-06-30
- 主分类号: A61K31/045
- IPC分类号: A61K31/045 ; A61B1/273 ; A61B1/31 ; A61K9/107 ; A61K47/02 ; A61K47/10 ; A61K47/26 ; A61K47/34 ; A61K47/44 ; A61K49/00
摘要:
It is known that L-menthol controls smooth muscle contraction. In order to use L-menthol in practice as a digestive tract contraction inhibiting agent in digestive tract endoscopy, it is required to devise means of giving a formulation in which an L-menthol-containing formulation remains stable and transparent or little cloudy over a long time after the production and which shows little foaming at the administration. In the present invention, an antifoaming agent is further added to a formulation for inhibiting smooth muscle contraction or a peristaltic contraction in a digestive tract containing a L-menthol emulsion having an average particle size of less than 100nm. Thus, it is possible to obtain a formulation that remains stable over a long time, has a high light transmittance, and produces little foam when filled into a container and sprayed at a target area to inhibit contraction to facilitate observation of the area in endoscopic examination of the digestive tract etc.
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