Gamma radiation imaging system for non-destructive inspection of the luggage contains a DR sub-system, which obtains the projected image of the luggage by translationally scanning, and a CT sub-system, which obtains the tomograph image of the luggage by rotating scanning. Said DR sub-system includes a fixed gantry, a conveyor system, a radiation source mounted on the fixed gantry, front and back collimators, and the array detector. Said CT sub-system includes a rotating gantry, a conveyor system, a radiation source mounted on the rotating gantry, front and back collimators, and the array detector, wherein, the radiation source in said CT sub-system is 192 Ir or 75 Se radioactive isotope gamma source with high specific activity. Said gamma source is enclosed in a shield chamber with a projecting opening. The shield chamber is mounted on said rotating gantry. Said array detector is adapted for detecting gamma ray of 192 Ir or 75 Se radioactive isotope; The radiation source in said DR sub-system is 192 Ir or 75 Se radioactive isotope gamma source with high specific activity, said gamma source is enclosed in a shield chamber with a projecting opening. The shield chamber is mounted on said fixed gantry. Said array detector is adapted for detecting gamma ray of 192 Ir or 75 Se radioactive isotope.