发明公开
- 专利标题： MACROCYCLIC BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE
- 专利标题（中）： 大环β-分泌阿尔茨海默氏病的治疗
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申请号： EP04780598.1申请日： 2004-08-10
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公开(公告)号： EP1656359A2公开(公告)日： 2006-05-17
- 发明人: COBURN, Craig , STACHEL, Shawn, J. , VACCA, Joseph, P.
- 申请人： Merck & Co., Inc.
- 申请人地址： 126 East Lincoln Avenue Rahway, New Jersey 07065-0907 US
- 专利权人： Merck & Co., Inc.
- 当前专利权人： Merck & Co., Inc.
- 当前专利权人地址： 126 East Lincoln Avenue Rahway, New Jersey 07065-0907 US
- 代理机构： Man, Jocelyn
- 优先权： US495667P 20030814
- 国际公布： WO2005018545 20050303
- 主分类号： C07D267/22
- IPC分类号： C07D267/22 ; C07D225/04 ; A61K31/33 ; A61P25/28
摘要：
The present invention is directed to compounds which are inhibitors of the beta-secretase enzyme and that are useful in the treatment or prevention of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the beta-secretase enzyme is involved.
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