发明公开
- 专利标题： HLA-A *01-binding T-cell epitope of WT1
- 专利标题（中）： HLA-A * 01结合T-Zell-Epitop von WT1
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申请号： EP04026827.8申请日： 2004-11-11
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公开(公告)号： EP1657250A1公开(公告)日： 2006-05-17
- 发明人: Scheibenbogen, Carmen , Asemissen, Anne Marie , Stevanovic, Stefan , Keilholz, Ulrich
- 申请人： Charité - Universitätsmedizin Berlin
- 申请人地址： Schumannstrasse 20/21 10117 Berlin DE
- 专利权人： Charité - Universitätsmedizin Berlin
- 当前专利权人： Charité - Universitätsmedizin Berlin
- 当前专利权人地址： Schumannstrasse 20/21 10117 Berlin DE
- 代理机构： Engelhard, Markus
- 主分类号： C07K14/47
- IPC分类号： C07K14/47 ; A61K39/00 ; C07K7/04 ; G01N33/574 ; C12Q1/68
摘要：
The present invention refers to an immunogenic HLA-A*01-binding T-cell epitope of the Wilms' tumour 1 protein (WT1) and its utility as a target in immunotherapy. In more detail, the invention refers to a polypeptide comprising an amino acid sequence as depicted in SEQ ID NO: 1, to an antibody directed to said polypeptide, to a polynucleotide encoding said amino acid sequence and to a polynucleotide which is complementary to said polynucleotide. The invention further refers to pharmaceutical compositions and in vitro applications.
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