发明授权
EP1660440B1 ACYLOXYALKYL CARBAMATE PRODRUGS, METHODS OF SYNTHESIS AND USE
有权
ACYLOXYALKYLCARBAMAT-PRODRUGS,SYNTHESEVERFAHREN UND ANWENDUNG
- 专利标题: ACYLOXYALKYL CARBAMATE PRODRUGS, METHODS OF SYNTHESIS AND USE
- 专利标题(中): ACYLOXYALKYLCARBAMAT-PRODRUGS,SYNTHESEVERFAHREN UND ANWENDUNG
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申请号: EP04781926.3申请日: 2004-08-20
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公开(公告)号: EP1660440B1公开(公告)日: 2012-02-22
- 发明人: GALLOP, Mark, A. , YAO, Fenmei , LUDWIKOW, Maria, J. , PHAN, Thu , PENG, Ge
- 申请人: XenoPort, Inc.
- 申请人地址: 3410 Central Expressway Santa Clara, CA 95051 US
- 专利权人: XenoPort, Inc.
- 当前专利权人: XenoPort, Inc.
- 当前专利权人地址: 3410 Central Expressway Santa Clara, CA 95051 US
- 代理机构: Wytenburg, Wilhelmus Johannes
- 优先权: US496938P 20030820; US606637P 20040813
- 国际公布: WO2005019163 20050303
- 主分类号: C07C271/22
- IPC分类号: C07C271/22 ; A61K31/195
摘要:
The disclosures herein relate generally to acyloxyalkyl carbamate prodrugs of (±) 4 amino 3 (4 chlorophenyl)butanoic acid and analogs thereof, pharmaceutical compositions thereof , methods of making prodrugs of (±) 4 amino 3 (4 chlorophenyl)butanoic acid and analogs thereof, methods of using prodrugs of (±) 4 amino 3 (4 chlorophenyl)butanoic acid and analogs thereof, and pharmaceutical compositions thereof for treating or preventing common diseases and/or disorders such as spasticity and/or acid reflux disease. The disclosures herein also relate to acyloxyalkyl carbamate prodrugs of (±) 4 amino 3 (4 chlorophenyl)butanoic acid and analogs thereof which are suitable for oral administration and to sustained release oral dosage forms thereof.
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