发明授权
EP1664299B1 RNA INTERFERENCE MEDIATED INHIBITION OF VASCULAR ENDOTHELIAL GROWTH FACTOR AND VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA)
有权
通过RNA干扰介导的表达血管内皮和血管内皮的生长因子使用短干扰核酸基因受体的生长因子的基因的抑制率（的siNA）
- 专利标题： RNA INTERFERENCE MEDIATED INHIBITION OF VASCULAR ENDOTHELIAL GROWTH FACTOR AND VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA)
- 专利标题（中）： 通过RNA干扰介导的表达血管内皮和血管内皮的生长因子使用短干扰核酸基因受体的生长因子的基因的抑制率（的siNA）
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申请号： EP04784372.7申请日： 2004-09-16
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公开(公告)号： EP1664299B1公开(公告)日： 2009-05-13
- 发明人: JADHAV, Vasant , KOSSEN, Karl , ZINNEN, Shawn , VAISH, Narendra , MCSWIGGEN, James
- 申请人： Sirna Therapeutics, Inc.
- 申请人地址： 2950 Wilderness Place Boulder, CO 80301 US
- 专利权人： Sirna Therapeutics, Inc.
- 当前专利权人： Sirna Therapeutics, Inc.
- 当前专利权人地址： 2950 Wilderness Place Boulder, CO 80301 US
- 代理机构： Rollins, Anthony John
- 优先权： US665255 20030916; US664767 20030916; US670011 20030923; US693059 20031023; US720448 20031124; US727780 20031203; US757803 20040114; US764957 20040126; US543480P 20040210; US780447 20040213; US826966 20040416; US831620 20040423; PCT/US2004/013456 20040430; US844076 20040511
- 国际公布： WO2005028649 20050331
- 主分类号： C12N15/11
- IPC分类号： C12N15/11 ; C12P19/34 ; C07H21/02 ; C07H21/04 ; A01N43/04
摘要：
This invention relates to compounds, compositions, and methods useful for modulating VEGF and/or VEGFR gene expression using short interfering nucleic acid (siNA) molecules. This invention also relates to compounds, compositions, and methods useful for modulating the expression and activity of other genes involved in pathways of VEGF and/or VEGFR gene expression and/or activity by RNA interference (RNAi) using small nucleic acid molecules. In particular, the instant invention features small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules and methods used to modulate the expression of VEGF and/or VEGFR genes.
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