发明公开
EP1666518A4 HYALURONIC ACID MODIFICATION PRODUCTS AND DRUG CARRIERS USING THEM
有权
HYALUORNSÄURE-MODIFIZIERUNGSPRODUKTE UNDARZNEISTOFFTRÄGERDAMIT
- 专利标题: HYALURONIC ACID MODIFICATION PRODUCTS AND DRUG CARRIERS USING THEM
- 专利标题(中): HYALUORNSÄURE-MODIFIZIERUNGSPRODUKTE UNDARZNEISTOFFTRÄGERDAMIT
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申请号: EP04787709申请日: 2004-09-08
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公开(公告)号: EP1666518A4公开(公告)日: 2006-11-29
- 发明人: HIRAKURA TAI , NAKAMURA TERUO , SHIMOBOJI TSUYOSHI
- 申请人: CHUGAI PHARMACEUTICAL CO LTD
- 专利权人: CHUGAI PHARMACEUTICAL CO LTD
- 当前专利权人: CHUGAI PHARMACEUTICAL CO LTD
- 优先权: JP2003315387 2003-09-08; JP2003407681 2003-12-05; JP2004259157 2004-09-07
- 主分类号: C08G85/00
- IPC分类号: C08G85/00 ; A61K9/51 ; C08B37/08 ; C08G63/00 ; C08G63/91
摘要:
There is provided a drug carrier which has solved the problems of conventional drug carriers, which can encapsulate a low molecular drug efficiently, which can control a sustained release period for a long term, which can control blood residence, which has high dispersibility in an aqueous solution, and which is not problematical in safety. A drug carrier, which comprises injectable fine particles minimal in agglomeration between the particles, and which has excellent biocompatibility, is also provided. A hyaluronic acid modification product comprising hyaluronic acid or its derivative, and a polymer bonded together, the polymer being selected from polylactic acid, polyglycolic acid and lactic acid-glycolic acid copolymer, according to the present invention, provides a drug carrier which encapsulates a low molecular drug efficiently, which can control a sustained release period for a long term, which can control blood residence, which is well dispersible in an aqueous solution, and which is not problematical in safety. The hyaluronic acid modification product of the present invention also provides a drug carrier comprising injectable fine particles minimal in agglomeration between the particles, and having excellent biocompatibility.
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