发明公开
- 专利标题： COMBINATION METHODS OF TREATING CANCER
- 专利标题（中）： 复合体方法治疗癌症的
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申请号： EP04780925.6申请日： 2004-08-12
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公开(公告)号： EP1667680A2公开(公告)日： 2006-06-14
- 发明人: BACOPOULOS, Nicholas G. , CHIAO, Judy, H. , MARKS, Paul, A. , MILLER, Thomas, A. , PARADISE, Carolyn, M. , RICHON, Victoria, M. , RIFKIND, Richard, A.
- 申请人： Aton Pharma, Inc. , Sloan-Kettering Institute For Cancer Research
- 申请人地址： 33 Avenue Louis Pasteur Boston, MA 02115 US
- 专利权人： Aton Pharma, Inc.,Sloan-Kettering Institute For Cancer Research
- 当前专利权人： Aton Pharma, Inc.,Sloan-Kettering Institute For Cancer Research
- 当前专利权人地址： 33 Avenue Louis Pasteur Boston, MA 02115 US
- 代理机构： Crump, Julian Richard John
- 优先权： US498803P 20030829
- 国际公布： WO2005023179 20050317
- 主分类号： A61K31/44
- IPC分类号： A61K31/44 ; A61K31/19
摘要：
The present invention relates to a method of treating cancer in a subject in need thereof, by administering to a subject in need thereof a first amount of a histone deacetylase (HDAC) inhibitor or a pharmaceutically acceptable salt or hydrate thereof, in a first treatment procedure, and a second amount of an anti-cancer agent in a second treatment procedure. The first and second amounts together comprise a therapeutically effective amount. The effect of the HDAC inhibitor and the anti-cancer agent may be additive or synergistic.
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