发明公开
- 专利标题: PACKAGING CELLS FOR RECOMBINANT ADENOVIRUS
- 专利标题(中): 包装细胞FOR重组腺病毒
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申请号: EP04791140.9申请日: 2004-10-04
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公开(公告)号: EP1670925A1公开(公告)日: 2006-06-21
- 发明人: VOGELS, Ronald , HAVENGA, Menzo, Jans, Emco , ZUIJDGEEST, David A.T.M.
- 申请人: Crucell Holland B.V.
- 申请人地址: Archimedesweg 4 2333 CN Leiden NL
- 专利权人: Crucell Holland B.V.
- 当前专利权人: Crucell Holland B.V.
- 当前专利权人地址: Archimedesweg 4 2333 CN Leiden NL
- 代理机构: Verhage, Richard Abraham
- 优先权: PCT/EP03/50679 20031002
- 国际公布: WO2005033320 20050414
- 主分类号: C12N15/86
- IPC分类号: C12N15/86 ; C12N5/10
摘要:
In the absence of substantial sequence overlap between a recombinant adenoviral vector and the genome of a packaging cell, helper dependent El-containing particles (HDEP) can be formed at low frequency. The invention provides means and methods reducing or preventing the generation of HDEP. To this purpose, novel packaging cells and methods of making these are provided.
公开/授权文献
- EP1670925B1 PACKAGING CELLS FOR RECOMBINANT ADENOVIRUS 公开/授权日:2013-05-01
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