发明授权
- 专利标题： PENICILLIN CRYSTAL AND PROCESS FOR PRODUCING THE SAME
- 专利标题（中）： 青霉素晶体和方法及其
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申请号： EP04773756.4申请日： 2004-10-08
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公开(公告)号： EP1671974B1公开(公告)日： 2010-12-08
- 发明人: WADA, Isao, c/o OTSUKA CHEMICAL CO., LTD. , KAMEYAMA, Yutaka, c/o OTSUKA CHEMICAL CO., LTD.
- 申请人： Otsuka Chemical Co., Ltd. , TAIHO PHARMACEUTICAL CO., LTD.
- 申请人地址： 2-27, Otedori 3-chome, Chuo-ku Osaka-shi, Osaka 540-0021 JP
- 专利权人： Otsuka Chemical Co., Ltd.,TAIHO PHARMACEUTICAL CO., LTD.
- 当前专利权人： Otsuka Chemical Co., Ltd.,TAIHO PHARMACEUTICAL CO., LTD.
- 当前专利权人地址： 2-27, Otedori 3-chome, Chuo-ku Osaka-shi, Osaka 540-0021 JP
- 代理机构： Barz, Peter
- 优先权： JP2003350406 20031009
- 国际公布： WO2005035539 20050421
- 主分类号： C07D499/00
- IPC分类号： C07D499/00
摘要：
2β-chloromethyl-2α-methylpenam-3α-carboxylic acid benzhydryl ester (CMPB) crystals having excellent stability; and a process for producing CMPB crystals which comprises (A) the step of concentrating a CMPB-containing solution, (B) the step of subjecting the resultant concentrate to column chromatography, (C) the step of concentrating a CMPB-containing fraction, and (D) the step of dissolving the resultant CMPB-containing concentrate in an ether solvent and subsequently adding a hydrocarbon solvent to this solution to precipitate CMPB crystals.
公开/授权文献
- EP1671974A1 PENICILLIN CRYSTAL AND PROCESS FOR PRODUCING THE SAME 公开/授权日：2006-06-21
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