发明公开
- 专利标题： TAO KINASE MODULATORS AND METHODS OF USE
- 专利标题（中）： 陶激酶和调制器的使用方法
-
申请号： EP04796442.4申请日： 2004-10-22
-
公开(公告)号： EP1678121A2公开(公告)日： 2006-07-12
- 发明人: BALY, Deborah, Lynn , GALAN, Adam, Antoni , IBRAHIM, Mohamed, Abdulkader , JAEGER, Christopher , KEARNEY, Patrick , LEAHY, James, William , LEWIS, Gary, Lee , MCMILLAN, Kirk , NOGUCHI, Robin, Tammie , NUSS, John, M. , PARKS, Jason, Jevious , SCHNEPP, Kevin, Luke , SHI, Xian , WILLIAMS, Matthew, Alan , XU, Wei , ZHANG, Wentao
- 申请人： Exelixis, Inc.
- 申请人地址： 170 Harbor Way, P.O. Box 511 South San Francisco, CA 94083-0511 US
- 专利权人： Exelixis, Inc.
- 当前专利权人： Exelixis, Inc.
- 当前专利权人地址： 170 Harbor Way, P.O. Box 511 South San Francisco, CA 94083-0511 US
- 代理机构： Grünecker, Kinkeldey, Stockmair & Schwanhäusser Anwaltssozietät
- 优先权： US514377P 20031024
- 国际公布： WO2005040355 20050506
- 主分类号： C07C233/64
- IPC分类号： C07C233/64 ; C07C275/06 ; C07C275/28 ; A61K31/16 ; A61K31/17
摘要：
The invention provides compounds and methods for inhibition of kinases, such as those of the TAO family, more specifically KIAA1361, TAO, and JIK kinases. The invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. Compounds of the invention inhibit, regulate and/or modulate kinase receptor signal transduction pathways related to the changes in cellular activities as mentioned above, and the invention includes compositions which contain these compounds, and methods of using them to treat kinase-dependent diseases and conditions.
信息查询
