发明公开
- 专利标题： TRANSGENIC FLIES EXPRESSING MUTANT ALPFA42
- 专利标题（中）： 转基因果蝇，突变ALPHA42表达
-
申请号： EP04795934.1申请日： 2004-10-21
-
公开(公告)号： EP1684574A1公开(公告)日： 2006-08-02
- 发明人: LOWE, David, A. , CUMMINGS, Christopher, J. , KEONIG, Gerhard
- 申请人： Envivo Pharmaceuticals, Inc.
- 申请人地址： 790 Memorial Drive, Suite 102 Cambridge, MA 02139 US
- 专利权人： Envivo Pharmaceuticals, Inc.
- 当前专利权人： Envivo Pharmaceuticals, Inc.
- 当前专利权人地址： 790 Memorial Drive, Suite 102 Cambridge, MA 02139 US
- 代理机构： Maschio, Antonio
- 优先权： US512970P 20031021; US513149P 20031021; US513152P 20031021; US512972P 20031021; US512913P 20031021; US852973 20040525; US853593 20040525; US852951 20040525; US852974 20040525; US852892 20040525
- 国际公布： WO2005041650 20050512
- 主分类号： A01K67/033
- IPC分类号： A01K67/033 ; G01N33/00
摘要：
The present invention discloses a transgenic fly that expresses the Iowa mutant version of the human Aβ42 peptide of human amyloid-β precursor protein (APP), and a double transgenic fly that expresses both the Tau protein and the human AβIowa peptide of human amyloid-β precursor protein (APP). The transgenic flies of the present invention provide for models of neurodegenerative disorders, such as Alzheimer's disease. The invention further discloses methods for identifying genetic modifiers, as well as screening methods to identify therapeutic compounds to treat neurodegenerative disorders using the transgenic flies.
信息查询
