发明授权
EP1684750B1 2-AMINOARYLOXAZOLE COMPOUNDS AS TYROSINE KINASE INHIBITORS
有权
2- AMINOARYLOXAZOL化合物作为酪氨酸激酶抑制剂
- 专利标题： 2-AMINOARYLOXAZOLE COMPOUNDS AS TYROSINE KINASE INHIBITORS
- 专利标题（中）： 2- AMINOARYLOXAZOL化合物作为酪氨酸激酶抑制剂
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申请号： EP04791783.6申请日： 2004-10-22
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公开(公告)号： EP1684750B1公开(公告)日： 2010-04-28
- 发明人: MOUSSY, Alain , WERMUTH, Camille , GRIERSON, David , BENJAHAD, Abdellah , CROISY, Martine , CIUFOLINI, Marco , GIETHLEN, Bruno
- 申请人： AB Science , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) , Institut Curie
- 申请人地址： 3, avenue George V 75008 Paris FR
- 专利权人： AB Science,CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS),Institut Curie
- 当前专利权人： AB Science,CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS),Institut Curie
- 当前专利权人地址： 3, avenue George V 75008 Paris FR
- 代理机构： Portal, Frédéric
- 优先权： US513214P 20031023
- 国际公布： WO2005040139 20050506
- 主分类号： A61K31/422
- IPC分类号： A61K31/422
摘要：
The present invention relates to novel compounds selected from 2-aminoaryloxazoles of formula I that selectively modulate, regulate, and/or inhibit signal transduction mediated by certain native and/or mutant tyrosine kinases implicated in a variety of human and animal diseases such as cell proliferative, metabolic, allergic, and degenerative disorders. More particularly, these compounds are potent and selective c-kit, bcr-abl, FGFR3 and/or Flt-3 inhibitors.
公开/授权文献
- EP1684750A2 2-AMINOARYLOXAZOLE COMPOUNDS AS TYROSINE KINASE INHIBITORS 公开/授权日：2006-08-02
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