发明公开
- 专利标题： A NOVEL PROCESS FOR EZETIMIBE INTERMEDIATE
- 专利标题（中）： 新方法一依泽替米贝中间体
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申请号： EP03773997.6申请日： 2003-11-24
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公开(公告)号： EP1687287A1公开(公告)日： 2006-08-09
- 发明人: PARTHASARADHI REDDY, B., Hetero House , RATHNAKAR REDDY, K., Hetero Drugs Limited (R & D) , RAJI REDDY, R., Hetero Drugs Limited (R & D) , MURALIDHARA REDDY, D., Hetero Drugs Limited (R&D) , SUBASH CHANDER REDDY, K., Hetero Drugs Ltd. (R&D)
- 申请人： Hetero Drugs Limited
- 申请人地址： Hetero House, 8-3-166/7/1, Erragadda Hyderabad 500 018, Andhrapradesh IN
- 专利权人： Hetero Drugs Limited
- 当前专利权人： Hetero Drugs Limited
- 当前专利权人地址： Hetero House, 8-3-166/7/1, Erragadda Hyderabad 500 018, Andhrapradesh IN
- 代理机构： Green, Mark Charles
- 国际公布： WO2005049592 20050602
- 主分类号： C07D291/04
- IPC分类号： C07D291/04
摘要：
The invention provides a process for preparing intermediate of ezetimibe, which shows hypocholesterolemic activity. Thus 3-[5-(4-fluorophenyl)-1,5-dioxopentyl]-4-phenyl-2-oxazolidinone is reduced with (-)-DIP chloride to obtain 3-[(5S)-5-(4-fluorophenyl)-5-hydroxy-1-oxopentyl]-4-phenyl-2-oxazolidinone.
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