发明公开
- 专利标题： PEGYLATED SMALL MOLECULES
- 专利标题（中）： 单分散的聚乙二醇化的组合物含有络-
-
申请号： EP04814802.7申请日： 2004-12-16
-
公开(公告)号： EP1694363A2公开(公告)日： 2006-08-30
- 发明人: BENTLEY, Michael, D. , VIEGAS, Tacey, X. , GOODIN, Richard, R. , CHENG, Lin , ZHAO, Xuan
- 申请人： Nektar Therapeutics Al, Corporation
- 申请人地址： 490 Discovery Drive Huntsville, AL 35806 US
- 专利权人： Nektar Therapeutics Al, Corporation
- 当前专利权人： Nektar Therapeutics Al, Corporation
- 当前专利权人地址： 490 Discovery Drive Huntsville, AL 35806 US
- 代理机构： Baldock, Sharon Claire
- 优先权： US530122P 20031216
- 国际公布： WO2005058367 20050630
- 主分类号： A61K47/48
- IPC分类号： A61K47/48 ; C08G65/08
摘要：
The invention provides small molecule drugs that are chemically modified by covalent attachment of a water-soluble oligomer obtained from a monodisperse or bimodal water-soluble oligomer composition. A conjugate of the invention, when administered by any of a number of administration routes, exhibits a reduced biological membrane crossing rate as compared to the biological membrane crossing rate of the small molecule drug not attached to the water-soluble oligomer.
公开/授权文献
- EP1694363B1 Monodisperse PEGylated naloxol compositions 公开/授权日：2014-01-22
信息查询
