发明公开
EP1694838A2 RNA INTERFERENCE MEDIATED INHIBITION OF GPRA AND AAA1 GENE EXPRESSION USING SHORT NUCLEIC ACID (siNA)
审中-公开
RNA干扰介导的GPRA- AND AAA1基因表达的抑制使用新浪（短干扰核酸）
- 专利标题： RNA INTERFERENCE MEDIATED INHIBITION OF GPRA AND AAA1 GENE EXPRESSION USING SHORT NUCLEIC ACID (siNA)
- 专利标题（中）： RNA干扰介导的GPRA- AND AAA1基因表达的抑制使用新浪（短干扰核酸）
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申请号： EP04781836.4申请日： 2004-08-20
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公开(公告)号： EP1694838A2公开(公告)日： 2006-08-30
- 发明人: RICHARDS, Ivan , POLISKY, Barry , MCSWIGGEN, James
- 申请人： Sirna Therapeutics, Inc.
- 申请人地址： 2950 Wilderness Place Boulder, CO 80301 US
- 专利权人： Sirna Therapeutics, Inc.
- 当前专利权人： Sirna Therapeutics, Inc.
- 当前专利权人地址： 2950 Wilderness Place Boulder, CO 80301 US
- 代理机构： Maschio, Antonio
- 优先权： US693059 20031023; US720448 20031124; US727780 20031203; US757803 20040114; US543480P 20040210; US780447 20040213; US826966 20040416; PCT/US2004/013456 20040430; US570086P 20040511; PCT/US2004/016390 20040524
- 国际公布： WO2005045038 20050519
- 主分类号： C12N15/11
- IPC分类号： C12N15/11
摘要：
This invention relates to compounds, compositions, and methods useful for modulating G protein-coupled receptor for asthma susceptibility (GPRA) and asthma-associated alternatively spliced gene 1 (AAA1) gene expression using short interfering nucleic acid (siNA) molecules. This invention also relates to compounds, compositions, and methods useful for modulating the expression and activity of other genes involved in pathways of GPRA and/or AAA1 gene expression and/or activity by RNA interference (RNAi) using small nucleic acid molecules. In particular, the instant invention features small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules and methods used to modulate the expression of GPRA and/or AAA1 genes.
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