发明公开
EP1697378A2 INDOLES, 1H-INDAZOLES, 1,2-BENZISOXAZOLES, AND 1,2-BENZISOTHIAZOLES, AND PREPARATION AND USES THEREOF
有权
吲哚，1H-吲唑，1,2-苯并异恶唑和-1,2-苯并异噻唑及其制备和应用
- 专利标题： INDOLES, 1H-INDAZOLES, 1,2-BENZISOXAZOLES, AND 1,2-BENZISOTHIAZOLES, AND PREPARATION AND USES THEREOF
- 专利标题（中）： 吲哚，1H-吲唑，1,2-苯并异恶唑和-1,2-苯并异噻唑及其制备和应用
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申请号： EP04814981.9申请日： 2004-12-22
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公开(公告)号： EP1697378A2公开(公告)日： 2006-09-06
- 发明人: XIE, Wenge , HERBERT, Brian , MA. Jianguo , NGUYEN, Truc Minh , SCHUMACHER, Richard, A. , GAUSS, Carla-Maria , TEHIM, Ashok
- 申请人： Memory Pharmaceuticals Corporation
- 申请人地址： 100 Philips Parkway Montvale, NJ 07645 US
- 专利权人： Memory Pharmaceuticals Corporation
- 当前专利权人： Memory Pharmaceuticals Corporation
- 当前专利权人地址： 100 Philips Parkway Montvale, NJ 07645 US
- 代理机构： Pfenning, Meinig & Partner GbR
- 优先权： US530891P 20031222; US606897P 20040903
- 国际公布： WO2005063767 20050714
- 主分类号： C07D487/18
- IPC分类号： C07D487/18 ; A61K31/4995 ; A61P25/00
摘要：
The present invention relates generally to the field of ligands for nicotinic acetylcholine receptors (nAChR), activation of nAChRs, and the treatment of disease conditions associated with defective or malfunctioning nicotinic acetylcholine receptors, especially of the brain. Further, this invention relates to novel compounds for example, indoles, 1H-indazoles, 1,2-benzisoxazoles, and 1,2-benzisothiazoles, which act as ligands for the α7 nAChR subtype, methods of preparing such compounds, compositions containing such compounds, and methods of use thereof.
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