发明公开
EP1697508A2 CRYSTAL STRUCTURE OF INTERLEUKIN-2 TYROSINE KINASE (ITK) AND BINDING POCKETS THEREOF
审中-公开
晶体结构的白细胞介素-2酪氨酸激酶（ICT）和IT结合位点
- 专利标题： CRYSTAL STRUCTURE OF INTERLEUKIN-2 TYROSINE KINASE (ITK) AND BINDING POCKETS THEREOF
- 专利标题（中）： 晶体结构的白细胞介素-2酪氨酸激酶（ICT）和IT结合位点
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申请号： EP04813070.2申请日： 2004-12-03
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公开(公告)号： EP1697508A2公开(公告)日： 2006-09-06
- 发明人: CHEETHAM, Graham , BROWN, Kieron , KNEGTEL, Ronald , RENWICK, Suzanne , VIAL, Sarah
- 申请人： Vertex Pharmaceuticals, Inc.
- 申请人地址： 130 Waverly Street Cambridge, MA 02139 US
- 专利权人： Vertex Pharmaceuticals, Inc.
- 当前专利权人： Vertex Pharmaceuticals, Inc.
- 当前专利权人地址： 130 Waverly Street Cambridge, MA 02139 US
- 代理机构： Vossius & Partner
- 优先权： US527372P 20031205; US3787 20041203
- 国际公布： WO2005056785 20050623
- 主分类号： C12N9/12
- IPC分类号： C12N9/12 ; C07K14/71
摘要：
The invention relates to molecules or molecular complexes which comprise binding pockets of ITK or its structural homologues. The invention relates to crystallizable compositions and crystals comprising ITK. The present invention also relates to a data storage medium encoded with the structural coordinates of molecules and molecular complexes which comprise the ITK or ITK-like ATP-binding pockets. The present invention also relates to a computer comprising such data storage material. The computer may generate a three-dimensional structure or graphical three-dimensional representation of such molecules or molecular complexes. This invention also relates to methods of using the structure coordinates to solve the structure of homologous proteins or protein complexes. In addition, this invention relates to methods of using the structure coordinates to screen for and design compounds, including inhibitory compounds, that bind to ITK or homologues thereof.
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