发明公开
- 专利标题： HETEROCYCLIC ASPARTYL PROTEASE INHIBITORS
- 专利标题（中）： 异烟肼ASPARTYL-PROTEASEHEMMER
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申请号： EP04813947.1申请日： 2004-12-13
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公开(公告)号： EP1699455A1公开(公告)日： 2006-09-13
- 发明人: ZHU, Zhaoning , MCKITTRICK, Brian , SUN, Zhong-Yue , YE, Yuanzan, C. , STRICKLAND, Corey , SMITH, Elizabeth, M. , STAMFORD, Andrew , GREENLEE, William, J. , WU, Yusheng , ISERLOH, Ulrich , MAZZOLA, Robert , CALDWELL, John , CUMMING, Jared , WANG, Lingyan , GUO, Tao , LE, Thuy, X. H. , SAIONZ, Kurt, W. , BABU, Suresh, D. , VOIGT, Johannes H. , HUNTER, Rachael C.
- 申请人： SCHERING CORPORATION , Pharmacopeia Drug Discovery, Inc.
- 申请人地址： 2000 Galloping Hill Road Kenilworth New Jersey 07033 US
- 专利权人： SCHERING CORPORATION,Pharmacopeia Drug Discovery, Inc.
- 当前专利权人： SCHERING CORPORATION,Pharmacopeia Drug Discovery, Inc.
- 当前专利权人地址： 2000 Galloping Hill Road Kenilworth New Jersey 07033 US
- 代理机构： Adams, Harvey Vaughan John
- 优先权： US529535P 20031215
- 国际公布： WO2005058311 20050630
- 主分类号： A61K31/4168
- IPC分类号： A61K31/4168 ; A61K31/4178 ; C07D233/88 ; C07D239/22 ; C07D271/06 ; C07D401/04 ; C07D401/10 ; C07D401/12 ; C07D401/14 ; C07D403/06 ; C07D403/10 ; C07D403/14 ; C07D405/06 ; C07D405/14 ; C07D407/14
摘要：
Disclosed are compounds of the formula (I) or a stereoisomer, tautomer, or pharmaceutically acceptable salt or solvate thereof. Also disclosed is the method of inhibiting aspartyl protease, and in particular, the methods of treating cardiovascular diseases, cognitive and neurodegenerative diseases, and the methods of inhibiting of Human Immunodeficiency Virus, plasmepins, cathepsin D and protozoal enzymes. Also disclosed are methods of treating cognitive or neurodegenerative diseases using the compounds of formula (I) in combination with a cholinesterase inhibitor or a muscarinic antagonist.
公开/授权文献
- EP1699455B1 HETEROCYCLIC ASPARTYL PROTEASE INHIBITORS 公开/授权日：2013-05-08
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