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发明授权
EP1699822B1 IL-7 FUSION PROTEINS WITH ANTIBODY PORTIONS, THEIR PREPARATION AND THEIR USE 有权
WITH抗体部分，它们的制备及其用途IL-7融合蛋白

  • 专利标题： IL-7 FUSION PROTEINS WITH ANTIBODY PORTIONS, THEIR PREPARATION AND THEIR USE
  • 专利标题（中）： WITH抗体部分，它们的制备及其用途IL-7融合蛋白
  • 申请号： EP04804151.1
    申请日： 2004-12-21
  • 公开(公告)号： EP1699822B1
    公开(公告)日： 2008-04-23
  • 发明人: LAUDER, Scott , GILLIES, Stephen, D.
  • 申请人： Merck Patent GmbH
  • 申请人地址： Frankfurter Strasse 250 64293 Darmstadt DE
  • 专利权人： Merck Patent GmbH
  • 当前专利权人： Merck Patent GmbH
  • 当前专利权人地址： Frankfurter Strasse 250 64293 Darmstadt DE
  • 优先权： US533406P 20031230
  • 国际公布： WO2005063820 20050714
  • 主分类号： C07K14/54
  • IPC分类号： C07K14/54 ;  C12N15/62 ;  A61K38/04
IL-7 FUSION PROTEINS WITH ANTIBODY PORTIONS, THEIR PREPARATION AND THEIR USE
摘要：
The invention relates to interleukin-7 (IL-7) fusion proteins, methods of their production and uses thereof. The fusion proteins comprise an immunoglobulin portion fused directly or indirectly to IL-7, which was modified at specific positions as compared to the wild­type IL-7 in order to improve biological and pharmaceutical properties. The proteins of the invention are particularly useful in treating disorders accompanied by immune deficiencies and particularly diseases which involve T-cell deficiencies.
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