发明公开
- 专利标题： Oncolytic virus
- 专利标题（中）： Onkolytisches病毒
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申请号： EP05025974.6申请日： 2000-09-18
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公开(公告)号： EP1716858A2公开(公告)日： 2006-11-02
- 发明人: Bell, John Cameron , Sonenberg, Nahum , Stojdl, David Francis , Brown, Earl Garnet , Atkins, Harold Lawrence , Marius, Ricardo Marcellus , Lichty, Brian Dennis , Knowles, Shane Brendan
- 申请人： Wellstat Biologics Corporation
- 申请人地址： 930 Clopper Road Gaithersburg, MD 20878 US
- 专利权人： Wellstat Biologics Corporation
- 当前专利权人： Wellstat Biologics Corporation
- 当前专利权人地址： 930 Clopper Road Gaithersburg, MD 20878 US
- 代理机构： MacLean, Martin Robert
- 优先权： US397873 19990917
- 主分类号： A61K35/76
- IPC分类号： A61K35/76
摘要：
The present invention is directed to a method of reducing the viability of a tumor cell involving administering a virus that is not a common human pathogen to the tumor cell. Preferably, the virus exhibits differential susceptibility, in that normal cells are not affected by the virus. This differential susceptibility is more pronounced in the presence of interferon. The tumor cell is characterised by having low levels, or no PKR activity, or as being PKR-/-, STAT1-/- or both PKR-/- and STAT-/-. The virus is selected from the group consisting of Rhabdovirus and picornavirus, and preferably is vesicular stomatitis virus (VSV) or a derivative thereof.
公开/授权文献
- EP1716858B9 Oncolytic virus 公开/授权日：2009-08-12
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