发明公开
EP1717313A4 NUCLEIC ACID PROBE, NUCLEIC ACID CHIP, METHOD OF DETECTING TARGET NUCLEIC ACID, METHOD OF SCREENING DRUG, APPARATUS FOR DETECTING TARGET NUCLEIC ACID AND GENE DIAGNOSIS METHOD
审中-公开
NUCLEIC探针核酸芯片，检测方法的靶核酸的，积极的检查方法，设备用于检测的靶核酸和GENDIAGNOSEVERFAHREN的
- 专利标题： NUCLEIC ACID PROBE, NUCLEIC ACID CHIP, METHOD OF DETECTING TARGET NUCLEIC ACID, METHOD OF SCREENING DRUG, APPARATUS FOR DETECTING TARGET NUCLEIC ACID AND GENE DIAGNOSIS METHOD
- 专利标题（中）： NUCLEIC探针核酸芯片，检测方法的靶核酸的，积极的检查方法，设备用于检测的靶核酸和GENDIAGNOSEVERFAHREN的
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申请号： EP04787923申请日： 2004-09-21
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公开(公告)号： EP1717313A4公开(公告)日： 2007-11-14
- 发明人: AOYAMA YASUHIRO , SANDO SHINSUKE , SASAKI TOSHINORI , NARITA ATSUSHI
- 申请人： UNIV KYOTO
- 专利权人： UNIV KYOTO
- 当前专利权人： UNIV KYOTO
- 优先权： JP2003329619 2003-09-22
- 主分类号： C12N15/11
- IPC分类号： C12N15/11 ; C12M1/00 ; C12Q1/68 ; G01N33/53 ; G01N33/566
摘要：
A nucleic acid probe for highly sensitively, highly accurately and quickly detecting a target nucleic acid in a trace amount which is designed so that, after hybridization with the target nucleic acid, the nucleic acid probe undergoes a structural change, thus shows a lowered binding force in the hybridization and, in its turn, is detached from the target nucleic acid. This nucleic acid probe comprises a cleavage part which is hybridizable with the target nucleic acid and, upon the hybridization with the target nucleic acid, cleaved to thereby give a first probe fragment and a second probe fragment at least one of which can be detached from the target nucleic acid, and a signal generation part capable of generating a signal. This nucleic acid probe has a cleavage part at which it is cleaved upon the hybridization with the target nucleic acid and, until the hybridization with the target nucleic acid, parts of the nucleic acid probe are hybridized with each other in its molecule to form a locked structure.
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