发明公开
EP1718276A2 INHALANT FORMULATION CONTAINING SULFOALKYLETHER CYCLODEXTRIN AND CORTICOSTEROID PREPARED FROM A UNIT DOSE SUSPENSION
审中-公开
吸入剂和配方磺烷基醚环糊精的皮质类固醇实现了从单个悬架
- 专利标题： INHALANT FORMULATION CONTAINING SULFOALKYLETHER CYCLODEXTRIN AND CORTICOSTEROID PREPARED FROM A UNIT DOSE SUSPENSION
- 专利标题（中）： 吸入剂和配方磺烷基醚环糊精的皮质类固醇实现了从单个悬架
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申请号： EP05704919.9申请日： 2005-01-03
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公开(公告)号： EP1718276A2公开(公告)日： 2006-11-08
- 发明人: ZIMMERER, Rupert, O. , THOMPSON, Diane, O. , MOSHER, Gerold, L. , PIPKIN, James, D.
- 申请人： Cydex Inc.
- 申请人地址： 10513 W. 84th Terrace Lenexa, KS 66214 US
- 专利权人： Cydex Inc.
- 当前专利权人： Cydex Inc.
- 当前专利权人地址： 10513 W. 84th Terrace Lenexa, KS 66214 US
- 代理机构： Weber, Thomas
- 优先权： US533628P 20031231
- 国际公布： WO2005065651 20050721
- 主分类号： A61K9/12
- IPC分类号： A61K9/12
摘要：
An inhalable unit dose liquid formulation containing SAE-CD and corticosteroid is provided. The formulation is adapted for administration to a subject by nebulization with any known nebulizer. The formulation can be included in a kit. The formulation is administered as an aqueóus solution or concentrated composition. The formulation is employed in an improved nebulization system for administering corticosteroid by inhalation. SAE-CD present in the formulation significantly enhances the chemical stability of corticosteroid, such as budesonide. A method of administering the formulation by inhalation is provided. The formulation can also be administered by conventional nasal delivery apparatus. The formulation is prepared by mixing SAE-CD, in solid or liquid (dissolved) form, with an inhalable suspension-based unit dose formulation.
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