发明公开
- 专利标题： BRAS ESPACEUR MOLECULAIRE, PROCEDE DE FABRICATION, ET UTILISATIONS SUR UNE PUCE D ANALYSE A MOLECULES OU BIOMOLECULES
- 专利标题（英）： Molecular spacer, production method thereof and uses of same on an analysis chip with molecules or biomolecules
- 专利标题（中）： 分子间隔，欲使用方法和分析与分子或芯片 生物分子
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申请号： EP05728104.0申请日： 2005-02-22
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公开(公告)号： EP1718657A1公开(公告)日： 2006-11-08
- 发明人: PERETTI, Véronique , VINET, Françoise , BONNAFFE, David
- 申请人： COMMISSARIAT A L'ENERGIE ATOMIQUE
- 申请人地址： 25, rue Leblanc Immeuble "Le Ponant D" 75015 Paris FR
- 专利权人： COMMISSARIAT A L'ENERGIE ATOMIQUE
- 当前专利权人： COMMISSARIAT A L'ENERGIE ATOMIQUE
- 当前专利权人地址： 25, rue Leblanc Immeuble "Le Ponant D" 75015 Paris FR
- 代理机构： Poulin, Gérard
- 优先权： FR0450346 20040225
- 国际公布： WO2005085263 20050915
- 主分类号： C07H3/02
- IPC分类号： C07H3/02 ; G01N33/543
摘要：
The invention relates to a molecular spacer, to a method of fixing a molecular unit to a solid support and to the use of said spacer on analysis chips with molecules or biomolecules. According to the invention, the spacer has formula (I) wherein: X0, X4 = C, O, S, Se, N, P, As; X1-3 = C, O, N, S, Se, P, As, or aryl, heteroaryl at C1-6; Z1-2 = C-R, Si-R, N, P and As, where R = alkyl at C1-6; R1-3 = H, or alkyl, aryl, heteroaryl at C1-6; [Gp] = protective group of >N; n, m and n = integers = 1; [Sup] = H or a silanised solid support; and [mo] = H or a molecular unit which is intended to be fixed covalently by means of the spacer to the silanised solid support.
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