发明公开
EP1720575A2 THERAPEUTIC AND DIAGNOSTIC CONJUGATES FOR USE WITH MULTISPECIFIC ANTIBODIES
有权
治疗和诊断缀合物具有多特异性抗体USE
- 专利标题: THERAPEUTIC AND DIAGNOSTIC CONJUGATES FOR USE WITH MULTISPECIFIC ANTIBODIES
- 专利标题(中): 治疗和诊断缀合物具有多特异性抗体USE
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申请号: EP05726492.1申请日: 2005-02-11
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公开(公告)号: EP1720575A2公开(公告)日: 2006-11-15
- 发明人: MCBRIDE, William J. , GOLDENBERG, David, M. , NOREN, Carl , HANSEN, Hans, J.
- 申请人: Immunomedics Inc.
- 申请人地址: 300 American Road Morris Plains, NJ 07950 US
- 专利权人: Immunomedics Inc.
- 当前专利权人: Immunomedics Inc.
- 当前专利权人地址: 300 American Road Morris Plains, NJ 07950 US
- 代理机构: Soames, Candida Jane
- 优先权: US776470 20040211
- 国际公布: WO2005077071 20050825
- 主分类号: A61K39/395
- IPC分类号: A61K39/395
摘要:
Disclosed are compounds that include two or more haptens conjugated by a spacer or a carrier. The haptens may include diethylenetriaminepentaacetate (DTPA), histimine-succinyl-glutamine (HSG), or combinations of DTPA and HSG. The compound also includes an effector molecule which may be conjugated to one or more of the haptens, the spacer/carrier, or both. The effector molecule may be conjugated by a number of linkages including an ester linkage, an imino linkage, an amino linkage, a sulfide linkage, a thiosemicarbazone linkage, a semicarbazone linkage, an oxime linkage, an ether linkage, or combinations of these linkages. Also disclosed are methods of synthesizing the compounds and/or precursors of the compounds.
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