发明公开
- 专利标题： VLA-4 ANTAGONISTS
- 专利标题（中）： VLA-4拮抗剂
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申请号： EP05729422.5申请日： 2005-03-07
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公开(公告)号： EP1725542A1公开(公告)日： 2006-11-29
- 发明人: HAGMANN, William, K. , LIN, Linus, S. , LIU, Ping , MUMFORD, Richard, A. , REGER, Thomas, S. , SMITH, Nicholas, D. , STOCK, Nicholas, S. , ZUNIC, Jasmine
- 申请人： Merck & Co., Inc.
- 申请人地址： 126 East Lincoln Avenue Rahway, NJ 07065-0907 US
- 专利权人： Merck & Co., Inc.
- 当前专利权人： Merck & Co., Inc.
- 当前专利权人地址： 126 East Lincoln Avenue Rahway, NJ 07065-0907 US
- 代理机构： Buchan, Gavin MacNicol
- 优先权： US552057P 20040310; US615477P 20041001
- 国际公布： WO2005087760 20050922
- 主分类号： C07D401/12
- IPC分类号： C07D401/12 ; C07D401/14 ; A61K31/44
摘要：
Compounds of Formula I are antagonists of VLA-4, and as such are useful in the inhibition or prevention of cell adhesion and cell-adhesion mediated pathologies. These compounds may be formulated into pharmaceutical compositions and are suitable for use in the treatment of inflammatory bowel disease including ulcerative colitis and Crohn’s disease, multiple sclerosis, asthma, and rheumatoid arthritis.
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