发明公开
EP1735306A2 INDAZOLES, BENZOTHIAZOLES, BENZOISOTHIAZOLES, BENZISOXAZOLES, AND PREPARATION AND USES THEREOF
审中-公开
吲唑，苯并噻唑，苯并异噻唑，异恶唑及其制备方法和用途
- 专利标题： INDAZOLES, BENZOTHIAZOLES, BENZOISOTHIAZOLES, BENZISOXAZOLES, AND PREPARATION AND USES THEREOF
- 专利标题（中）： 吲唑，苯并噻唑，苯并异噻唑，异恶唑及其制备方法和用途
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申请号： EP05745169.2申请日： 2005-03-25
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公开(公告)号： EP1735306A2公开(公告)日： 2006-12-27
- 发明人: XIE, Wenge , HERBERT, Brian , SCHUMACHER, Richard , NGUYEN, Truc, Minh , MA, Jianguo , GAUSS, Carla, Maria , TEHIM, Ashok
- 申请人： Memory Pharmaceuticals Corporation
- 申请人地址： 100 Philips Parkway Montvale, NJ 07645 US
- 专利权人： Memory Pharmaceuticals Corporation
- 当前专利权人： Memory Pharmaceuticals Corporation
- 当前专利权人地址： 100 Philips Parkway Montvale, NJ 07645 US
- 代理机构： Pfenning, Meinig & Partner GbR
- 优先权： US555951P 20040325; US616033P 20041006
- 国际公布： WO2005092890 20051006
- 主分类号： C07D453/02
- IPC分类号： C07D453/02 ; A61K31/439 ; A61P25/18 ; A61P25/24 ; A61P25/26 ; A61P25/28 ; A61P25/32
摘要：
The present invention relates generally to the field of ligands for nicotinic acetylcholine receptors (nACh receptors), activation of nACh receptors, and the treatment of disease conditions associated with defective or malfunctioning nicotinic acetylcholine receptors, especially of the brain. Further, this invention relates to novel compounds (e.g., indazoles and benzothiazoles), which act as ligands for the a7 nACh receptor subtype, methods of preparing such compounds, compositions containing such compounds, and methods of use thereof.
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