The invention relates to an insulated refrigerated portable box for drinks in the technical field of liquid storage devices and, more particularly, transportable storage devices, used to house, refrigerate and keep cool all types of liquids, in particular, drinks contained in flexible or rigid containers (for example of the plastic bottle type) and for drawing off drinks. Said insulated refrigerated portable box comprises a parallelepiped box (1), enclosing a container (6) containing a liquid, said container being provided with a means for drawing off (8) the liquid which may be brought outside said box, detachable refrigerating blocks (2), arranged against the internal lateral walls of said box, a layer of lagging material, arranged between said refrigerating blocks and said lateral walls, said layer of lagging material being formed by lagging sheets (3), coupled to said refrigerating blocks, by means of mechanical fixings such as to form fixed refrigerating block/lagging sheet assemblies. The insulated refrigerated box thus obtained can be used for housing, refrigerating and keeping cool drinks before being consumed cool, for example, water and certain wines. By placing the refrigerating blocks in said box, the user can enjoy a cool drink for several days without the need to place the same in a refrigerator.