发明公开
EP1753441A2 POLYPEPTIDES FOR INDUCING A PROTECTIVE IMMUNE RESPONSE AGAINST STAPHYLOCOCCUS AUREUS
审中-公开
用于诱导针对金黄色葡萄球菌的保护性免疫应答的多肽
- 专利标题： POLYPEPTIDES FOR INDUCING A PROTECTIVE IMMUNE RESPONSE AGAINST STAPHYLOCOCCUS AUREUS
- 专利标题（中）： 用于诱导针对金黄色葡萄球菌的保护性免疫应答的多肽
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申请号： EP05749169.8申请日： 2005-05-20
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公开(公告)号： EP1753441A2公开(公告)日： 2007-02-21
- 发明人: ANDERSON, Annaliesa, S.
- 申请人： Merck & Co., Inc.
- 申请人地址： 126 East Lincoln Avenue Rahway, NJ 07065-0907 US
- 专利权人： Merck & Co., Inc.
- 当前专利权人： Merck & Co., Inc.
- 当前专利权人地址： 126 East Lincoln Avenue Rahway, NJ 07065-0907 US
- 代理机构： Horgan, James Michael Frederic
- 优先权： US574032P 20040525
- 国际公布： WO2005115113 20051208
- 主分类号： A61K38/00
- IPC分类号： A61K38/00 ; A61K39/085 ; A61K39/02 ; C07K1/00
摘要：
The present invention features polypeptides comprising an amino acid sequence structurally related to SEQ ID NO: 1 and uses of such polypeptides. SEQ ID NO: 1 is a derivative of a full length S. aureus polypeptide. The full-length naturally occurring polypeptide is referred to herein as full length “ORF0826”. The SEQ ID NO: 1 derivative contains an alanine addition after the initial methionine. A His-tag derivative of SEQ ID NO: 1 was found to produce a protective immune response against S. aureus.
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