发明公开
EP1756106A1 CYCLOHEXYLALANINE DERIVATIVES AS DIPEPTIDYL PEPTIDASE-IV INHIBITORS FOR THE TREATMENT OR PREVENTION OF DIABETES
审中-公开
CYCLOHEXYLALANINDERIVATE ALS二肽基肽酶IV抑制剂为糖尿病治疗或预防
- 专利标题： CYCLOHEXYLALANINE DERIVATIVES AS DIPEPTIDYL PEPTIDASE-IV INHIBITORS FOR THE TREATMENT OR PREVENTION OF DIABETES
- 专利标题（中）： CYCLOHEXYLALANINDERIVATE ALS二肽基肽酶IV抑制剂为糖尿病治疗或预防
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申请号： EP05750136.3申请日： 2005-05-13
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公开(公告)号： EP1756106A1公开(公告)日： 2007-02-28
- 发明人: DUFFY, Joseph, L. , KAELIN, David, E., Jr. , WEBER, Ann, E. , KIRK, Brian, A.
- 申请人： Merck & Co., Inc.
- 申请人地址： 126 East Lincoln Avenue Rahway, NJ 07065-0907 US
- 专利权人： Merck & Co., Inc.
- 当前专利权人： Merck & Co., Inc.
- 当前专利权人地址： 126 East Lincoln Avenue Rahway, NJ 07065-0907 US
- 代理机构： Man, Jocelyn
- 优先权： US572065P 20040518
- 国际公布： WO2005116029 20051208
- 主分类号： C07D471/04
- IPC分类号： C07D471/04
摘要：
The present invention is directed to novel cyclohexylalanine derivatives which are inhibitors of the dipeptidyl peptidase-IV enzyme ('DP-IV inhibitors') and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.
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