发明公开
- 专利标题： ARYL-SUBSTITUTED PIPERAZINE DERIVATIVES
- 专利标题（中）： 芳基取代的哌嗪衍生物
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申请号： EP05760258.3申请日： 2005-06-16
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公开(公告)号： EP1756107A2公开(公告)日： 2007-02-28
- 发明人: HUTCHISON, Alan, J. , CHENARD, Bertrand, L. , LI, Guiying , GHOSH, Manuka , TARRANT, James, G. , YOON, Taeyoung , LUKE, George, P. , LEE, Kyungae , O'DONNELL, Mary-Margaret, E. , PRINGLE, Wallace, C. , PETERSON, John, M. , HODGETTS, Kevin, J. , STEENSTRA, Cheryl, K. , DOLLER, Dario
- 申请人： NEUROGEN CORPORATION
- 申请人地址： 35 N.E. Industrial Road Branford, CT 06405 US
- 专利权人： NEUROGEN CORPORATION
- 当前专利权人： NEUROGEN CORPORATION
- 当前专利权人地址： 35 N.E. Industrial Road Branford, CT 06405 US
- 代理机构： Smaggasgale, Gillian Helen
- 优先权： US580958P 20040617
- 国际公布： WO2006009789 20060126
- 主分类号： C07D471/04
- IPC分类号： C07D471/04 ; C07D487/08 ; C07D487/04 ; C07D211/74 ; C07D207/26 ; C07D207/08 ; C07D307/79 ; C07D295/08 ; C07D295/06 ; C07D211/34 ; A61P3/00
摘要：
Aryl-substituted piperazine derivatives are provided. Such compounds may be used to modulate MCH receptor activity in vivo or in vitro, and are particularly useful in the treatment of a variety of metabolic, feeding and sexual disorders in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for treating such disorders are provided, as are methods for using such ligands for detecting MCH receptors (e.g., receptor localization studies).
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