Embodiments of the present invention provide a device with an integrated low-noise parametric amplifier using a CCD-based structure with minimal noise gain. In one embodiment, a device which may be used for monitoring and/or diagnosing a human or an animal body comprises a CCD-based device including a first gate forming a first capacitor and a second gate forming a second capacitor, the first capacitor having a surface area larger than a surface area of the second capacitor; and a controller configured to input a signal to the CCD-based device; convert the input signal into a charge packet having a voltage associated therewith; transfer the charge packet from the first capacitor to the second capacitor of the CCD-based device, the voltage associated with the charge packet being multiplied by a ratio of the surface area of the first capacitor divided by the surface area of the second capacitor; and produce an amplified output signal from the multiplied voltage.