发明授权
EP1771426B1 DIPHENYLAMINSUBSTITUIERTE SALICYLTHIAZOLDERIVATE UND VERWANDTE VERBINDUNGEN ALS PHOSPHOTYROSINPHOSPHATASE 1B (PTP1B) HEMMER ZUR VERWENDUNG ALS BLUTZUCKERSENKENDE WIRKSTOFFE ZUR BEHANDLUNG VON DIABETES
有权
DIPHENYLAMINSUBSTITUIERTE SALICYLTHIAZOLDERIVATE及相关化合物AS磷酸酪氨酸磷酸酶1B（PTP1B）抑制剂FOR USE AS血糖降低物质对于糖尿病的治疗
- 专利标题： DIPHENYLAMINSUBSTITUIERTE SALICYLTHIAZOLDERIVATE UND VERWANDTE VERBINDUNGEN ALS PHOSPHOTYROSINPHOSPHATASE 1B (PTP1B) HEMMER ZUR VERWENDUNG ALS BLUTZUCKERSENKENDE WIRKSTOFFE ZUR BEHANDLUNG VON DIABETES
- 专利标题（英）： Diphenylamine-substituted salicylthiazole derivatives and related compounds as phosphotyrosine phosphatase 1b (ptp1b) inhibitors for using as blood-sugar decreasing active ingredients for treating diabetes
- 专利标题（中）： DIPHENYLAMINSUBSTITUIERTE SALICYLTHIAZOLDERIVATE及相关化合物AS磷酸酪氨酸磷酸酶1B（PTP1B）抑制剂FOR USE AS血糖降低物质对于糖尿病的治疗
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申请号： EP05756578.0申请日： 2005-07-02
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公开(公告)号： EP1771426B1公开(公告)日： 2007-12-19
- 发明人: PETRY, Stefan , BARINGHAUS, Karl-Heinz , TENNAGELS, Norbert , MUELLER, Guenter , KIRSCH, Reinhard
- 申请人： Sanofi-Aventis Deutschland GmbH
- 申请人地址： Brüningstrasse 50 65929 Frankfurt am Main DE
- 专利权人： Sanofi-Aventis Deutschland GmbH
- 当前专利权人： Sanofi-Aventis Deutschland GmbH
- 当前专利权人地址： Brüningstrasse 50 65929 Frankfurt am Main DE
- 优先权： DE102004034697 20040717
- 国际公布： WO2006007959 20060126
- 主分类号： C07D277/42
- IPC分类号： C07D277/42 ; C07D277/46 ; A61K31/426 ; A61P3/10
摘要：
The aim of the invention is to provide compounds having a therapeutic blood-sugar decreasing effect. Said compounds are suitable especially for the prevention and treatment of pancreatic diabetes. To this end, the invention relates to compounds of formula (I) wherein R1, R2, R3, R4, R5 independently represent H, F, Cl, Br, J, OH, CF3, NO2, CN, OCF3, O-(C1-C6)-alkyl, O-(C1-C4)-alkoxy-(C1-C4)-alkyl, S-(C1-C6)-alkyl, (C1-C6)-alkyl, (C2-C6)-alkenyl, (C3-C8)-cycloalkyl, O-(C3-C8)-cycloalkyl, (C3-C8)-cycloalkenyl, O-(C3-C8)-cycloalkenyl, (C2-C6)-alkinyl, aryl, O-aryl, (C1-C8)alkylene-aryl, O-(C1-C8)-alkylene-aryl, S-aryl, CO-NH(C1-C6)-alkyl, N((C1-C6)-alkyl)2, NH-SO2-CH3, SO2-CH3, COOH, COO-(C1-C6)-alkyl, or CO-N((C1-C6)-alkyl)2; R6 represents H, (C1-C6)-alkyl; A represents a bond, -CH2-, -NH-, -CH2-O-, -S-, -CH2-CH2-, or -CH(CH3)-; B represents NH, NH(C1-C4)-alkyl, or NH(CO); and D represents phenyl or a heterocycle. The invention also relates to the physiologically compatible salts of said compounds.
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