The invention concerns oxopiperidine derivatives of general formula (I) wherein: n = 1; Ra, Ra′, Rb et Rb′ represent hydrogen atoms or alkyl or cycloalkyl groups, or Rb and Rb′ together form a carbon bridge; R1 represents an alkyl or cycloalkyl group; R2 represents a heteroaryl group; R3 represents 1 to 3 groups selected among halogen atoms and alkyl, cycloalkyl, -OR, -NRR', -CO-NRR', -NR-CO-R', -NR-CO-NRR1, -NR-COOR', -NO2, -CN and COOR groups; R5 represents a hydrogen atom or an alkyl group; R4 is selected among the groups of formulae (a), (b) and (c), wherein p = 0, 1, 2 or 3, m = 0, 1 or 2, and X represents a -C(R6)(R7)- or -N(R10)- member. The invention also concerns a method for preparing said derivatives and their therapeutic use.