发明公开
- 专利标题： Genetically engineered bleb vaccine
- 专利标题（中）： Gentechnologisch hergestellter Bleb Impstoff
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申请号： EP06124088.3申请日： 2000-07-31
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公开(公告)号： EP1774977A2公开(公告)日： 2007-04-18
- 发明人: Berthet, Francois-Xavier Jacques , Dalemans, Wilfred L. J. , Denoel, Philippe , Dequesne, Guy , Feron, Christiane , Lobet, Yves , Poolman, Jan , Thiry, Georges , Thonnard, Joelle , Voet, Pierre
- 申请人： GlaxoSmithKline Biologicals S.A.
- 申请人地址： Rue de l'Institut, 89 1330 Rixensart BE
- 专利权人： GlaxoSmithKline Biologicals S.A.
- 当前专利权人： GlaxoSmithKline Biologicals S.A.
- 当前专利权人地址： Rue de l'Institut, 89 1330 Rixensart BE
- 代理机构： Lubienski, Michael John
- 优先权： GB9918319 19990803
- 主分类号： A61K39/095
- IPC分类号： A61K39/095
摘要：
The present invention relates to an immune-protective and non-toxic Gram-negative bleb vaccine suitable for paediatric use. Examples of the Gram-negative strains from which the blebs are made are N. meningitidis, M. catarrhalis and H. influenzae. The blebs of the invention are improved by one or more genetic changes to the chromosome of the bacterium, including up-regulation of protective antigens, down-regulation of immunodominant non-protective antigens, and detoxification of the Lipid A moiety of LPS.
公开/授权文献
- EP1774977A3 Genetically engineered bleb vaccine 公开/授权日：2007-07-04
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