发明公开
- 专利标题: TETRAHYDRO-NAPHTHALENE DERIVATIVES AS GLUCOCORTICOID RECEPTOR MODULATORS
- 专利标题(中): 四氢乙酰胆碱酯酶抑制剂
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申请号: EP05775926.8申请日: 2005-08-10
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公开(公告)号: EP1776119A1公开(公告)日: 2007-04-25
- 发明人: EDWARDS, Christine Argenta Discovery Limited , FENTON, Garry Argenta Discovery Limited , MACDONALD, Simon John Fawcett GlaxoSmithKline , WEINGARTEN, Gordon Gad GlaxoSmithKline
- 申请人: GLAXO GROUP LIMITED
- 申请人地址: Glaxo Wellcome House, Berkeley Avenue, Greenford, Middlesex UB6 ONN GB
- 专利权人: GLAXO GROUP LIMITED
- 当前专利权人: GLAXO GROUP LIMITED
- 当前专利权人地址: Glaxo Wellcome House, Berkeley Avenue, Greenford, Middlesex UB6 ONN GB
- 代理机构: Gladwin, Amanda Rachel
- 优先权: GB0418045 20040812
- 国际公布: WO2006015870 20060216
- 主分类号: A61K31/47
- IPC分类号: A61K31/47 ; C07D215/04 ; C07D217/04 ; A61K31/472 ; A61P17/00 ; A61P29/00
摘要:
The present invention is directed to compounds of formula (I): wherein R represents a methyl or an ethyl group X represents N, C-H or C-CH3 when X represents C-H or C-CH3, Y represents N when X represents N, Y represents C-H and physiologically functional derivatives thereof, pharmaceutical compositions comprising the compounds, the use of the compounds for the manufacture of medicaments particularly for the treatment of inflammatory and/or allergic conditions, processes for the preparation of the compounds, and chemical intermediates in the processes for the manufacture of the compounds.
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