发明公开
EP1784493A2 ADENOVIRAL VECTORS ABLE TO TRANSDUCE APCS, POTENTIAL USE IN IMMUNE RESPONSE GENERATION
审中-公开
有能力的腺病毒载体TO CONVERTING APCS，潜在用途免疫应答GENERATION
- 专利标题： ADENOVIRAL VECTORS ABLE TO TRANSDUCE APCS, POTENTIAL USE IN IMMUNE RESPONSE GENERATION
- 专利标题（中）： 有能力的腺病毒载体TO CONVERTING APCS，潜在用途免疫应答GENERATION
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申请号： EP05808866.7申请日： 2005-08-30
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公开(公告)号： EP1784493A2公开(公告)日： 2007-05-16
- 发明人: NABEL, Gary J. , CHENG, Cheng , GALL, Jason G. D. , WICKHAM, Thomas J., EMD Lexigen Bedford Campus
- 申请人： The Government of the United States of America as Represented by The Department of Health and Human Services , GenVec, Inc.
- 申请人地址： Suite 325 6011 Executive Boulevard Rockville, MD 20852 US
- 专利权人： The Government of the United States of America as Represented by The Department of Health and Human Services,GenVec, Inc.
- 当前专利权人： The Government of the United States of America as Represented by The Department of Health and Human Services,GenVec, Inc.
- 当前专利权人地址： Suite 325 6011 Executive Boulevard Rockville, MD 20852 US
- 代理机构： Wössner, Gottfried
- 优先权： US606273P 20040901
- 国际公布： WO2006039045 20060413
- 主分类号： C12N15/861
- IPC分类号： C12N15/861 ; A61K39/00
摘要：
The invention provides a method of inducing an immune response in a mammal. The method comprises administering to the mammal an adenoviral vector comprising (a) a subgroup C fiber protein wherein a native coxsackievirus and adenovirus receptor (CAR)-binding site is disrupted, (b) a subgroup C penton base protein wherein a native integrin-binding site is disrupted, and (c) a nucleic acid sequence encoding at least one antigen derived from an infectious agent other than an adenovirus which is expressed in the mammal to induce an immune response.
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