发明授权
EP1802748B1 THERMOSTABLE MUTANTS OF PYRROLOQUINOLINE QUINONE DEPENDENT GLUCOSE DEHYDROGENASE
有权
THERMO稳定的突变体吡咯CHINON依赖葡萄糖脱氢酶
- 专利标题： THERMOSTABLE MUTANTS OF PYRROLOQUINOLINE QUINONE DEPENDENT GLUCOSE DEHYDROGENASE
- 专利标题（中）： THERMO稳定的突变体吡咯CHINON依赖葡萄糖脱氢酶
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申请号： EP05792997.8申请日： 2005-10-14
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公开(公告)号： EP1802748B1公开(公告)日： 2011-06-01
- 发明人: BOENITZ-DULAT, Mara , KRATZSCH, Peter , SCHMUCK, Rainer
- 申请人： Roche Diagnostics GmbH , F. Hoffmann-La Roche AG
- 申请人地址： Sandhofer Strasse 116 68305 Mannheim DE
- 专利权人： Roche Diagnostics GmbH,F. Hoffmann-La Roche AG
- 当前专利权人： Roche Diagnostics GmbH,F. Hoffmann-La Roche AG
- 当前专利权人地址： Sandhofer Strasse 116 68305 Mannheim DE
- 优先权： EP04024593 20041015
- 国际公布： WO2006040172 20060420
- 主分类号： C12N9/04
- IPC分类号： C12N9/04 ; C12N15/53 ; C12Q1/32
摘要：
The present invention relates to a mutant protein of PQQ-dependent s-GDH characterized in that in at least one of the positions 122 and 124 the amino acid lysine is present, wherein these positions correspond to the amino acid positions known from the A. calcoaceticus s-GDH wild-type sequence (SEQ ID NO: 2), it also discloses genes encoding such mutant s-GDH, and different applications of these sGDH mutants, particularly for determining the concentration of glucose in a sample.
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