发明公开
EP1805169A1 HISTAMINE H3 RECEPTOR INHIBITORS, THEIR PREPARATION AND THERAPEUTIC USES
有权
组胺H3受体抑制剂，生产和治疗应用
- 专利标题： HISTAMINE H3 RECEPTOR INHIBITORS, THEIR PREPARATION AND THERAPEUTIC USES
- 专利标题（中）： 组胺H3受体抑制剂，生产和治疗应用
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申请号： EP05804419.9申请日： 2005-10-11
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公开(公告)号： EP1805169A1公开(公告)日： 2007-07-11
- 发明人: JESUDASON, Cynthia, Darshini , STEVENS, Freddie, Craig
- 申请人： ELI LILLY AND COMPANY
- 申请人地址： Eli Lilly Corporate Center Indianapolis, IN 46285 US
- 专利权人： ELI LILLY AND COMPANY
- 当前专利权人： ELI LILLY AND COMPANY
- 当前专利权人地址： Eli Lilly Corporate Center Indianapolis, IN 46285 US
- 代理机构： Suarez-Miles, Ana Sanchiz
- 优先权： US619785P 20041018
- 国际公布： WO2006044228 20060427
- 主分类号： C07D409/12
- IPC分类号： C07D409/12 ; C07D417/12 ; C07D405/12 ; C07D413/12 ; A61K31/4025 ; A61P25/00
摘要：
The present invention provides novel compounds with histamine-H3 receptor antagonist or inverse agonist activity. In particular, the invention provides a compound of Formula I, or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising the compounds, methods of treatment employing these compounds and compositions, and intermediates and methods for making these compounds. The invention provides methods of using compounds and pharmaceutical compositions to treat obesity, cognitive deficiencies, narcolepsy, and other histamine H3 receptor-related diseases.
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