发明公开
EP1805314A2 VERFAHREN ZUR ENANTIOSELEKTIVEN ÖFFNUNG VON 3-SUBSTITUIERTEN OXETAN-2-ONEN UNTER EINWIRKUNG DER LIPASEN VON CANDIDA ANTARCTICA ODER BURKHOLDERIA PLANTARII
有权
使用南极假丝酵母或植物伯克霍尔德氏菌脂肪酶OF 3-取代氧杂环丁烷-2-酮类方法对映选择性OPENING
- 专利标题： VERFAHREN ZUR ENANTIOSELEKTIVEN ÖFFNUNG VON 3-SUBSTITUIERTEN OXETAN-2-ONEN UNTER EINWIRKUNG DER LIPASEN VON CANDIDA ANTARCTICA ODER BURKHOLDERIA PLANTARII
- 专利标题（英）： Method for enantioselectively opening 3-substituted oxetan-2-ones under the action of lipases of candida antarctica or burkholderia plantarrii
- 专利标题（中）： 使用南极假丝酵母或植物伯克霍尔德氏菌脂肪酶OF 3-取代氧杂环丁烷-2-酮类方法对映选择性OPENING
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申请号： EP05769677.5申请日： 2005-07-28
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公开(公告)号： EP1805314A2公开(公告)日： 2007-07-11
- 发明人: HABICHER, Tilo , STÜRMER, Rainer
- 申请人： BASF AKTIENGESELLSCHAFT
- 申请人地址： 67056 Ludwigshafen DE
- 专利权人： BASF AKTIENGESELLSCHAFT
- 当前专利权人： BASF AKTIENGESELLSCHAFT
- 当前专利权人地址： 67056 Ludwigshafen DE
- 优先权： DE102004037700 20040802; DE102004038589 20040806
- 国际公布： WO2006015727 20060216
- 主分类号： C12P7/24
- IPC分类号： C12P7/24 ; C12P7/40 ; C12P7/62 ; C12P17/02 ; C12P41/00
摘要：
The invention relates to a method for producing, in essence, enantiomer-pure 3-hydroxycarboxylic acids or esters of general formula (III) by reacting racemic oxetan-2-ones of general formula (I) with compounds R3-OH of general formula (II) in the presence of a lipase from Candida antarctica or Burkholderia plantarii, and separating the obtained products of formula (III) and (IV) from one another, and the radicals have the following meanings: R1, R2 and R3, independent of one another, represent H, C1-C10-substituted or unsubstituted alkyl, and substituted or unsubstituted aryl or hetaryl, whereby R1 and R2 cannot have the same meaning at the same time.
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