发明公开
EP1807426A2 SUBSTITUTED N-ARYL-1H-PYRAZOLOÝ3,4-b¨QUINOLIN-4-AMINES AND ANALOGS AS ACTIVATORS OF CASPASES AND INDUCERS OF APOPTOSIS
审中-公开
取代的N-芳基 - 1H-吡唑并[3,4-b]喹啉-4-胺和它们的类似物作为胱天蛋白酶的活化剂和细胞凋亡诱导
- 专利标题： SUBSTITUTED N-ARYL-1H-PYRAZOLOÝ3,4-b¨QUINOLIN-4-AMINES AND ANALOGS AS ACTIVATORS OF CASPASES AND INDUCERS OF APOPTOSIS
- 专利标题（中）： 取代的N-芳基 - 1H-吡唑并[3,4-b]喹啉-4-胺和它们的类似物作为胱天蛋白酶的活化剂和细胞凋亡诱导
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申请号： EP05818244.5申请日： 2005-10-06
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公开(公告)号： EP1807426A2公开(公告)日： 2007-07-18
- 发明人: ZHANG, Han-Zhong , CAI, Sui, Xiong , DREWE, John, A.
- 申请人： Cytovia, Inc.
- 申请人地址： 6650 Nancy Ridge Drive San Diego, CA 92121 US
- 专利权人： Cytovia, Inc.
- 当前专利权人： Cytovia, Inc.
- 当前专利权人地址： 6650 Nancy Ridge Drive San Diego, CA 92121 US
- 代理机构： Schlich, George William
- 优先权： US616539P 20041007
- 国际公布： WO2006041900 20060420
- 主分类号： C07D471/04
- IPC分类号： C07D471/04 ; A61K31/437
摘要：
The present invention is directed to substituted N-aryl-1H-pyrazolo[3,4-b]quinolin-4-amines and analogs thereof, represented by the general Formula (I): wherein Q, Y, Z, R4-R7, X and Ar are defined herein. The present invention also relates to the discovery that compounds having Formula (I) are activators of caspases and inducers of apoptosis. Therefore, the activators of caspases and inducers of apoptosis of this invention can be used to induce cell death in a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.
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