发明公开
EP1808444A1 Amyloid beta protein (globular assembly and usees thereof)
失效
淀粉样蛋白β蛋白（globularer Aufbau und Verwendungen）
- 专利标题： Amyloid beta protein (globular assembly and usees thereof)
- 专利标题（中）： 淀粉样蛋白β蛋白（globularer Aufbau und Verwendungen）
-
申请号： EP06026771.3申请日： 1998-02-05
-
公开(公告)号： EP1808444A1公开(公告)日： 2007-07-18
- 发明人: Krafft, Grant, A. , Klein, William, L. , Chromy, Brett, A. , Lambert, Mary, P. , Finch, Caleb, E. , Morgan, Todd , Wals, Pat , Rozovsky, Irina , Barlow, Ann
- 申请人： Northwestern University , THE UNIVERSITY OF SOUTHERN CALIFORNIA
- 申请人地址： 633 Clark Street Evanston Illinois 60208 US
- 专利权人： Northwestern University,THE UNIVERSITY OF SOUTHERN CALIFORNIA
- 当前专利权人： Northwestern University,THE UNIVERSITY OF SOUTHERN CALIFORNIA
- 当前专利权人地址： 633 Clark Street Evanston Illinois 60208 US
- 代理机构： O'Connell, Maura
- 优先权： US796089 19970205
- 主分类号： C07K14/47
- IPC分类号： C07K14/47 ; G01N33/68
摘要：
The invention provides amyloid beta-derived dementing ligands (ADDLs) that comprise amyloid β protein assembled into globular non-fibrillar oligomeric structures capable of activating specific cellular processes. The invention also provides methods for assying the formation, presence, receptor protein binding and cellular activity of ADDLs, as well as compounds that block the formation or activity of ADDLs, and methods of identifying such compounds. The invention further provides methods of using ADDLs, and modulating ADDL formation and/or activity, inter alia in the treatment of learning and/or memory disorders.
信息查询
