发明公开
EP1809639A2 8A, 9-DIHYDRO-4A-H-ISOTHIAZOLO[5,4-B] QUINOLINE-3, 4-DIONES AND RELATED COMPOUNDS AS ANTI-INFECTIVE AGENTS
有权
如图8A所示，9-二氢4A-H - 异噻唑并[5,4-b]喹啉3,4-二酮和相关化合物感染的保护产品
- 专利标题： 8A, 9-DIHYDRO-4A-H-ISOTHIAZOLO[5,4-B] QUINOLINE-3, 4-DIONES AND RELATED COMPOUNDS AS ANTI-INFECTIVE AGENTS
- 专利标题（中）： 如图8A所示，9-二氢4A-H - 异噻唑并[5,4-b]喹啉3,4-二酮和相关化合物感染的保护产品
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申请号： EP05857829.5申请日： 2005-11-10
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公开(公告)号： EP1809639A2公开(公告)日： 2007-07-25
- 发明人: BRADBURY, Barton, James , DESHPANDE, Milind , PUCCI, Michael, John , WANG, Qiuping , WILES, Jason, Allan , SONG, Yongsheng , HASHIMOTO, Akihiro , LUCIEN, Edlaine
- 申请人： Achillion Pharmaceuticals, Inc.
- 申请人地址： 300 George Street New Haven, CT 06511 US
- 专利权人： Achillion Pharmaceuticals, Inc.
- 当前专利权人： Achillion Pharmaceuticals, Inc.
- 当前专利权人地址： 300 George Street New Haven, CT 06511 US
- 代理机构： Smaggasgale, Gillian Helen
- 优先权： US626961P 20041111
- 国际公布： WO2006118605 20061109
- 主分类号： C07D513/04
- IPC分类号： C07D513/04 ; A61K31/437 ; A61P31/04 ; A61P33/02
摘要：
The invention provides compounds and salts of Formula I and Formula II which possess antimicrobial activity. The invention also provides novel synthetic intermediates useful in making compounds of Formula I and Formula II. The variables n, m, p, RA, RB, A1, R2, R3, R5, R6, R7, A8 and R9 are defined herein. Certain compounds of Formula I and Formula II disclosed herein are potent and /or selective inhibitors of bacterial replication. The invention also provides antimicrobial compositions, including pharmaceutical compositions, containing one or more compounds of Formula I or Formula II and one or more carriers, excipients, or diluents. Such compositions may contain a compound of Formula I or Formula II as the only active agent or may contain a combination of a compound of Formula I or Formula II and one or more other active agents. The invention also provides methods for treating microbial infections in eukaryotes.
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