An ergonomic wrist rest (1) particularly for using computer keyboards and mice, which comprises at least one base element (2), which can be positioned proximate to a keyboard (T) or mouse (M) and has a lower face (3) which forms a resting surface for the base element (2) which is adapted to rest on a supporting surface (P). The device comprises at least one resting element (4), which is superimposed detachably on the base element (2) at an upper face (5) thereof which lies opposite the lower face (3) and faces a lower surface (23) of the resting element (4), the upper surface (25) of the resting element which lies opposite the lower surface forming a resting region for at least one wrist and detachable means for the connection of the resting element to the base element.