发明公开
EP1820800A1 Crystalline forms of duloxetine hydrochloride and processes for their preparation
审中-公开
Kristalline Formen von度洛西汀盐酸盐和Verfahren zu deren Herstellung
- 专利标题： Crystalline forms of duloxetine hydrochloride and processes for their preparation
- 专利标题（中）： Kristalline Formen von度洛西汀盐酸盐和Verfahren zu deren Herstellung
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申请号： EP06003244.8申请日： 2006-02-17
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公开(公告)号： EP1820800A1公开(公告)日： 2007-08-22
- 发明人: Stimac, Anton , Jakse, Renata , Zajc, Natalija , Zupet, Rok , Vajs, Anamarija
- 申请人： KRKA, tovarna zdravil, d.d., Novo mesto
- 申请人地址： Smarjeska cesta 6 8501 Novo mesto SI
- 专利权人： KRKA, tovarna zdravil, d.d., Novo mesto
- 当前专利权人： KRKA, tovarna zdravil, d.d., Novo mesto
- 当前专利权人地址： Smarjeska cesta 6 8501 Novo mesto SI
- 代理机构： Becker Kurig Straus
- 主分类号： C07D333/20
- IPC分类号： C07D333/20 ; A61K31/381
摘要：
The present invention relates to polymorphic forms of duloxetine hydrochloride, especially (duloxetine HCl), which are characterized by an X-ray diffraction pattern with peaks (2θ):9.6, 13.9, 18.0, 18.8, 19.2, 20.8, 27.4, 27.9 (designated form A) or an X-ray diffraction pattern with characteristic peaks (2θ): 12.0, 14.8, 19.8, 21.3, 21.6, 22.1, 22.4, 23.1, 24.1 (designated form T). The present invention also pertains to processes for the preparation of form A and form T, which involves dissolving duloxetine hydrochloride in particular solvents and cooling the solution to obtain crystals, that are dried.
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