The present invention describes compositions and methods for treating, preventing and improving the appearance of skin, particularly, treating, pr eventing, ameliorating, reducing and/or eliminating skin irritation, inflammation, a d/or the signs of visible or subjective discomfort, wherein the compositions include natural plant constituents that inhibit at least one cytokine. The plant e tracts are preferably derived from Populus nigra, Rhinacanthus nasutus, Sapindus rarak, and Thumbergia laurifolia, and any combinations thereof . The compositions are preferably applied to the skin, or are delivered by directed means, to a site in need thereof.