发明公开
- 专利标题： ANTIBODIES DIRECTED TO GPNMB AND USES THEREOF
- 专利标题（中）： 抗体GPNMB和用途
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申请号： EP05852645.0申请日： 2005-11-30
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公开(公告)号： EP1827492A2公开(公告)日： 2007-09-05
- 发明人: RASTELLI, Luca , POLLACK, Vincent, A. , TSE, Kam, Fai , KLAKAMP, Scott , FOORD, Orit , LIANG, Meina , JIA, Xiao-Chi , XIAO, Feng , LICHENSTEN, Henri , HERRMANN, John , LAROCHELLE, William, J. , JEFFERS, Michael, E. , CHAPOVAL, Andrei , MEZES, Peter , ARA, Gulshan , TORGOV, Michael , KARKARIA, Cyrus , DAVAGNINO, Juan
- 申请人： Curagen Corporation , Abgenix, Inc.
- 申请人地址： 322 East Main Street Brandford, CT 06405 US
- 专利权人： Curagen Corporation,Abgenix, Inc.
- 当前专利权人： Curagen Corporation,Abgenix, Inc.
- 当前专利权人地址： 322 East Main Street Brandford, CT 06405 US
- 代理机构： Peter, Beate
- 优先权： US632023P 20041130; US733779P 20051107
- 国际公布： WO2006071441 20060706
- 主分类号： A61K39/395
- IPC分类号： A61K39/395 ; A61K47/48 ; A61P35/00 ; C07K16/30 ; C07K19/00 ; C12N1/21 ; C12N15/13 ; C12N15/63 ; C12N5/10 ; G01N33/574 ; G01N33/577
摘要：
The present invention provides fully human lonoclonal antibodies that specifically bind to GPNMB, and uses thereof. Nucleotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions and/or complementarity determining regions (CDRs) are provided. The present invention also provides immunoconjugates comprising anti-GPNMB antibodies and methods of using such immunoconjugates. the present invention futher provides bispecific antibodies comprising an anti-GPNMB antibody component and an anti-CD3 component, and methods of using such bispecific antibodies.
公开/授权文献
- EP1827492B1 ANTIBODIES DIRECTED TO GPNMB AND USES THEREOF 公开/授权日：2010-08-11
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