Compounds of methamphetamine derivatives having a meta-substituted alkyl linker on the benzene ring and a protective group on the nitrogen of the methamphetamine hapten. Such compounds have the structure (I) wherein R1 is an alkyl linker comprising 2-15 carbon atoms and 0-6 heteroatoms, R2 is a leaving group, and R3 is a protecting group. Compounds having the formula (II), wherein R1 is an alkyl linker comprising 2-15 carbon atoms and 0-6 heteroatoms and R2 is a polysaccharide or a microparticle. Immunoassays for determining metamphetamine in a sample and test kits for use in determining methamphetamine in a sample.